Cardio-protective effects of Lipoic acid, Quercetin and Resveratrol on oxidative stress related to thyroid hormone alterations in long-term obesity

This study investigated possible mechanisms for cardio-protective effects of Lipoic acid (LA), Quercetin (Q) and Resveratrol (R) on oxidative stress related to thyroid hormone alterations in long-term obesity. Female C57BL/6 mice were fed on High-Fat Diet (HFD), HFD + LA, HFD + R, HFD + Q and normal diet for 26 weeks. Body weight, blood pressure, thyroid hormones, oxidative stress markers, angiotensin converting enzyme (ACE), nitric oxide synthase (NOS), ion pump activities were measured, and expression of cardiac genes analyzed by real time-PCR.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research