Effect of Dietary Docosahexaenoic Acid (DHA) in Phospholipids or Triglycerides on Brain DHA Uptake and Accretion

Tracer studies suggest that phospholipid DHA (PL-DHA) more effectively targets the brain than triglyceride DHA (TAG-DHA), although the mechanism and whether this translates into higher brain DHA concentrations are not clear. Rats were gavaged with [U-3H]PL-DHA and [U-3H]TAG-DHA and blood sampled over 6 hours prior to collection of brain regions and other tissues. In another experiment rats were supplemented for 4 weeks with TAG-DHA (fish oil), PL-DHA (roe PL) or a mixture of both for comparison to a low-omega-3 diet.

Source: The Journal of Nutritional Biochemistry - March 20, 2016 Category: Biochemistry Authors: Alex P. Kitson, Adam H. Metherel, Chuck T. Chen, Anthony F. Domenichiello, Marc-Olivier Trépanier, Alvin Berger, Richard P. Bazinet Source Type: research