Amelioration of obesity associated inflammation and insulin resistance in c57bl/6 mice via macrophage polarization by Fish oil supplementation

Enormous phenotypic plasticity makes macrophages the target cells in obesity associated inflammatory diseases. Thus, nutritional components that polarize macrophages towards anti-inflammatory phenotype can partially reverse inflammatory diseases like insulin resistance. In the present study, macrophage polarizing and insulin sensitizing properties of Fish oil (FO) were evaluated in high fat diet fed obese insulin resistant c57bl/6 mice (HFD-IR) after oral supplementation with FO (4, 8 or 16 mg/ kg bw) and compared to lean and HFD-IR mice.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research