Equol suppresses inflammatory response and bone erosion due to rheumatoid arthritis in mice

Rheumatoid arthritis (RA) is a chronic and systemic autoimmune inflammatory disease. Typical pathological findings of RA include persistent synovitis and bone degradation in the peripheral joints. Equol, a metabolite of the major soybean isoflavone daidzein, shows superior bioactivity than other isoflavones. We investigated the effects of equol administration on inflammatory response and bone erosion in mice with collagen-induced arthritis (CIA). The severity of arthritis symptoms was significantly low in the equol-administered CIA mice.

Source: The Journal of Nutritional Biochemistry - March 20, 2016 Category: Biochemistry Authors: I-Chian Lin, Shuya Yamashita, Motoki Murata, Motofumi Kumazoe, Hirofumi Tachibana Source Type: research