HES1 in immunity and cancer

The basic helix-loop-helix (bHLH) proteins are comprised of several proteins that function as transcription factors and play a regulatory role in several biochemical and physiological processes- differentiation, proliferation/cell-cycle arrest and survival/apoptosis. It was studies on neuronal cells that led to the cloning of two Hairy and Enhancer of Split (HES) proteins in 1992 [1]. There are presently seven Hes proteins (HES1-7) and they all exhibit homology at the amino-acid level of the bHLH domain [1–7].
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Mini review Source Type: research