Enhanced Osteogenesis of Adipose-Derived Stem Cells by Regulating Bone Morphogenetic Protein Signaling Antagonists and Agonists

This study demonstrates a novel strategy to maximize bone formation pathways in osteogenic differentiation of mesenchymal stem cells and functional bone formation by combining gene manipulation with a small molecule activator toward osteogenesis. The findings indicate promising stem cell-based therapy for treating bone defects that can effectively complement or replace current osteoinductive therapeutics.

Source: Stem Cells Translational Medicine - March 18, 2016 Category: Stem Cells Authors: Fan, J., Im, C. S., Guo, M., Cui, Z.-K., Fartash, A., Kim, S., Patel, N., Bezouglaia, O., Wu, B. M., Wang, C.-Y., Aghaloo, T. L., Lee, M. Tags: Tissue Engineering and Regenerative Medicine, Adipose-Derived Stem Cells Source Type: research