Adipose-Derived Stem Cells Induce Angiogenesis via Microvesicle Transport of miRNA-31

This study provides the evidence that microvesicles (MVs) from adipose-derived stem cells (ASCs), particularly from endothelial differentiation medium (EDM)-preconditioned ASCs, promote angiogenesis. An underlying mechanism of the proangiogenesis may be the delivery of microRNA-31 via MVs from ASCs to vascular endothelial cells in which factor-inhibiting HIF-1 is targeted and suppressed. The study findings reveal the role of MVs in mediating ASC-induced angiogenesis and suggest a potential MV-based angiogenic therapy for ischemic diseases.

Source: Stem Cells Translational Medicine - March 18, 2016 Category: Stem Cells Authors: Kang, T., Jones, T. M., Naddell, C., Bacanamwo, M., Calvert, J. W., Thompson, W. E., Bond, V. C., Chen, Y. E., Liu, D. Tags: Tissue-Specific Progenitor and Stem Cells, Adipose-Derived Stem Cells Source Type: research