Strategies and Challenges to Myocardial Replacement Therapy

This article outlines the advantages and limitations of the cell injection and patch approaches to cardiac regenerative therapy. If the field is to move forward, some fundamental questions require answers, including the limitations to the use of animal models for human cell-transplantation studies; the best way to measure success in terms of functional improvements, histological integration, electrical coupling, and arrhythmias; and where the cells should be applied for maximal benefit—the epicardium or the myocardium.
Source: Stem Cells Translational Medicine - Category: Stem Cells Authors: Tags: Perspectives, Tissue Engineering and Regenerative Medicine Source Type: research