ABC transporters as mediators of drug resistance and contributors to cancer cell biology
The extrusion of anticancer drugs by members of the ATP-binding cassette (ABC) transporter family is one of the most widely recognized mechanisms of multidrug resistance, and can be considered a hijacking of their normal roles in the transport of xenobiotics, metabolites and signaling molecules across cell membranes. While roles in cancer multidrug resistance have been clearly demonstrated for P-glycoprotein (P-gp), Breast Cancer Resistance Protein (BCRP) and Multidrug Resistance Protein 1 (MRP1), direct evidence for a role in multidrug resistance in vivo is lacking for other family members.
Source: Drug Resistance Updates - Category: Drugs & Pharmacology Authors: Jamie I. Fletcher, Rebekka T. Williams, Michelle J. Henderson, Murray D. Norris, Michelle Haber Source Type: research
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