Specific Removal of Alloreactive T-Cells To Prevent Gvhd In Hemopoietic Stem Cell Transplantation: Rationale, Strategies And Perspectives

Hemopoietic stem-cell transplantation (HSCT) is a standard procedure for treatment of malignant and non-malignant hematological diseases. HSCT donors include HLA-identical siblings, matched or mismatched unrelated donors and haploidentical related donors. Graft-versus-host disease (GvHD), mediated by donor alloreactive T-cells in the graft, can be triggered by minor histocompatibility antigens in HLA-identical pairs, by alleles at loci not considered for MUD-matching or by the mismatched haplotype in haplo-HSCT.
Source: Blood Reviews - Category: Hematology Authors: Tags: Review Source Type: research