AMPK{gamma}3 is dispensable for skeletal muscle hypertrophy induced by functional overload

In conclusion, our functional, transcriptional, and signaling data provide evidence against the involvement of the AMPK3 isoform in the regulation of skeletal muscle hypertrophy. Thus, the AMPK3 isoform is dispensable for functional overload-induced muscle growth. Mechanical loading can override signaling pathways that act as negative effectors of mTOR signaling and consequently promote skeletal muscle hypertrophy.

Source: AJP: Endocrinology and Metabolism - March 15, 2016 Category: Endocrinology Authors: Riedl, I., Osler, M. E., Björnholm, M., Egan, B., Nader, G. A., Chibalin, A. V., Zierath, J. R. Tags: Articles Source Type: research