STAT4 rs7574865 polymorphism in Iranian patients with rheumatoid arthritis

Conclusions Although most studies have proposed STAT4 polymorphisms as a susceptible risk factor for RA, we did not detect any significant association between the STAT4 polymorphism and RA in our study. Population-based studies help to identify genetic determinants of disease susceptibility. Possible explanations for differences in susceptible genetic factors among populations could be different genetic predispositions and contribution of gene–gene or gene–environment interactions.
Source: Indian Journal of Rheumatology - Category: Rheumatology Source Type: research