Morphological and nanomechanical changes in mechanosensitive endothelial cells induced by colloidal AFM probes

This article presents examples of how the colloidal AFM probes influence ECs during multiple scans. The results revealed that multiple scans of the ECs significantly influenced the morphology and elasticity of cells. Moreover, changes in the cell shape and mechanical properties were dependent on the scan direction (across or along the main axis of the cell). Multiple scans with a colloidal probe leaded to reorientation of the cell main axis and this effect was similar to the action of the shear stress induced by flow conditions. Furthermore, the correlation between the tip‐induced modification of the cell properties and the remodeling of the cell's glycocalyx was observed. SCANNING 9999:1–11, 2016. © 2016 Wiley Periodicals, Inc.
Source: Scanning - Category: Radiology Authors: Tags: Original Article Source Type: research