SUMOylation of DISC1: A Potential Role in Neural Progenitor Proliferation in the Developing Cortex

In this study, we report on the SUMOylation of DISC1. This posttranslational modification occurs on lysine residues where the small ubiquitin-related modifier (SUMO) and its homologs are conjugated to a large number of cellular proteins, which in turn regulates their subcellular distribution and protein stability. By using in silico, biochemical, and cell-biological approaches, we now demonstrate that human DISC1 is SUMOylated at one specific lysine 643 (K643). We also show that this residue is crucial for proper neural progenitor proliferation in the developing cortex.Mol Neuropsychiatry 2016;2:20-27
Source: Molecular Neuropsychiatry - Category: Neuroscience Source Type: research