Altered expression of intracellular Toll-like receptors in peripheral blood mononuclear cells from patients with alopecia areata

Conclusion: This is the first report that shows the comprehensive expression profile of TLRs in AA patients. We conclude that up-regulated expression of intracellular TLRs in PBMCs of AA patients may play an active role in abnormal regulation of Th-1, Th-17 and regulatory T cell cytokines in alopecia areata. General Significance: Targeting of TLRs and their associated inflammatory signaling will open new areas of research, this may lead to the development of novel therapeutic targets for the treatment of AA or other skin disorders.
Source: BBA Clinical - Category: Biochemistry Source Type: research