Endotoxin Exposure, Serum Vitamin D, Asthma and Wheeze Outcomes

Endotoxin has been shown to induce neutrophilic asthma and wheeze after binding toll-like receptor 4 to produce pro-inflammatory cytokines. Animal models have demonstrated that vitamin D might inhibit lipopolysaccharide-induced cytokines. However, whether endotoxin exposure and serum vitamin D deficiency interact to affect asthma and wheeze in humans has never been investigated in an epidemiological study.
Source: Respiratory Medicine CME - Category: Respiratory Medicine Authors: Source Type: research