Mechanism of pancreatic and liver malformations in human fetuses with short‐rib polydactyly syndrome

ConclusionIn SRP, there are differentiation defects of hepatocytes, cholangiocytes, and liver mesenchyme and, in rare cases, pancreatic mesenchymal anomalies. The morphological changes were subtle in early gestation but immunophenotypic abnormalities were present. Mesenchymal–epithelial interactions may contribute to the malformations. Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc.

Source: Birth Defects Research Part A: Clinical and Molecular Teratology - March 11, 2016 Category: Perinatology & Neonatology Authors: Christine K.C. Loo, Tamara N. Pereira, Mette Ramsing, Ida Vogel, Olav B. Petersen, Grant A. Ramm Tags: Original Research Article Source Type: research