Collagen VI deficiency reduces muscle pathology, but does not improve muscle function, in the {gamma}-sarcoglycan-null mouse

In conclusion, our results reveal that Collagen VI-mediated fibrosis contributes to skeletal muscle pathology in -sarcoglycan-null mice. Importantly, however, our data also demonstrate that a reduction in skeletal muscle pathology does not necessarily lead to an improvement of skeletal muscle function, and this should be considered in future translational studies.

Source: Human Molecular Genetics - March 11, 2016 Category: Genetics & Stem Cells Authors: de Greef, J. C., Hamlyn, R., Jensen, B. S., O'Campo Landa, R., Levy, J. R., Kobuke, K., Campbell, K. P. Tags: ARTICLES Source Type: research