Phosphatidylserine enhances IKBKAP transcription by activating the MAPK/ERK signaling pathway

In conclusion, our results demonstrate that PS activates the MAPK/ERK signaling pathway, resulting in activation of transcription factors that bind the promoter region of IKBKAP and thus enhancing its transcription. Therefore, compounds that activate the MAPK/ERK signaling pathway could constitute potential treatments for FD.

Source: Human Molecular Genetics - March 11, 2016 Category: Genetics & Stem Cells Authors: Donyo, M., Hollander, D., Abramovitch, Z., Naftelberg, S., Ast, G. Tags: ARTICLES Source Type: research