seed attenuates hepatic steatosis and promotes M2 macrophage polarization in high-fat diet–fed mice

In this study, we hypothesized that DWJ504, an extract of O ficus-indica seed, would ameliorate hepatic steatosis and inflammation by regulating hepatic de novo lipogenesis and macrophage polarization against experimental nonalcoholic steatohepatitis. Mice were fed a normal diet or a high-fat diet (HFD) for 10 weeks.

Source: Nutrition Research - December 12, 2015 Category: Nutrition Authors: Jung-Woo Kang, Jun-Kyu Shin, Eun-Ji Koh, Hyojeong Ryu, Hyoung Ja Kim, Sun-Mee Lee Tags: Original Research Source Type: research