Fucoidan alleviates high-fat diet-induced dyslipidemia and atherosclerosis in ApoE mice deficient in apolipoprotein E expression

AbstractFucoidan, a sulfated polysaccharide extracted from brown seaweeds, possesses many biological activities including anti-inflammatory and anti-oxidant activities. We aimed to investigate the protective effects of fucoidan on dyslipidemia and atherosclerosis in apolipoprotein E-deficient mice (ApoEshl mice) and to elucidate its molecular targets in the liver by using a transcriptomic approach. For 12 weeks, ApoEshl mice were fed a high-fat diet (HFD) supplemented with either 1% or 5% fucoidan.

Source: The Journal of Nutritional Biochemistry - March 8, 2016 Category: Biochemistry Authors: Takashi Yokota, Koichi Nomura, Mikio Nagashima, Naomi Kamimura Source Type: research