Effects of tamoxifen on traumatic brain injury-induced depression in male rats

Conclusion Our results suggest that intraperitoneal injection of TMX may ameliorate TBI-induced depression-like behavior in rats by increasing neuronal p-ERK1/2 expression, which may be associated with neuronal Bcl2 and BDNF expression and decreased neuronal apoptosis. This effect might represent a mechanism underlying the recovery from depression-like behavior.
Source: Formosan Journal of Surgery - Category: Surgery Source Type: research