Maternal vitamin C deficiency does not reduce hippocampal volume and β-tubulin III intensity in prenatal guinea pigs

Marginal vitamin C (vitC) deficiency affects 5-10% of adults including subpopulations such as pregnant women and newborns. Animal studies link vitC deficiency to deleterious effects on the developing brain, but exactly how the brain adapts to vitC deficiency and the mechanisms behind the observed deficits remain largely unknown. We hypothesized that vitC deficiency in utero may lead to a decreased neuronal maturation and increased cellular death giving rise to alterations of the hippocampal morphology in a guinea pig model.

Source: Nutrition Research - March 6, 2016 Category: Nutrition Authors: Stine N. Hansen, Janne G. Schjoldager, Maya D. Paidi, Jens Lykkesfeldt, Pernille Tveden-Nyborg Tags: Communication Source Type: research