Proprotein convertase 1/3 inhibited macrophages: A novel therapeutic based on drone macrophages

Publication date: Available online 5 March 2016 Source:EuPA Open Proteomics Author(s): Marie Duhamel, Franck Rodet, Adriana Murgoci, Maxence Wisztorski, Robert Day, Isabelle Fournier, Michel Salzet We demonstrated here thanks to proteomic, that proprotein convertase 1/3 knockdown macrophages present all the characteristic of activated pro-inflammatory macrophages. TLR4 and TLR9 signaling pathways can be enhanced leading to the secretion of pro-inflammatory factors and antitumor factors. We can control their activation by controlling one enzyme, PC1/3. In a tumor context, PC1/3 inhibition in macrophages may reactivate them and lead to a cytokine storm after stimulation “at distance” with a TLR ligand. Therefore, we name these proprotein convertase inhibited macrophages the “drone macrophages”. They constitute an innovative cell therapy to treat efficiently tumors. Graphical abstract

Source: EuPA Open Proteomics - March 7, 2016 Category: Bioinformatics Source Type: research