The transcription factor BATF modulates cytokine-mediated responses in T cells

The family of basic leucine zipper transcription factors, ATF-like (BATF) comprises three members (BATF, BATF2 and BATF3) and belongs to the group of AP-1 transcription factors. These factors are homo- or heterodimers composed of Jun, Fos or ATF/CREB proteins. They possess a DNA-binding domain (DBD) and a leucine zipper motif (bZIP), interestingly, all BATF isoforms lack the transactivation domain other AP-1 factors, such as Jun or Fos, have [1,2].
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Mini review Source Type: research