Dietary interesterified fat enriched with palmitic acid induces atherosclerosis by impairing macrophage cholesterol efflux and eliciting inflammation

Interesterified fats are currently being used to replace trans fatty acids. However, their impact on biological pathways involved in the atherosclerosis development was not investigated. Weaning male LDLr-KO mice were fed for 16 weeks on a high fat diet (40% energy as fat) containing polyunsaturated (PUFA), TRANS, palmitic (PALM), palmitic interesterified (PALM INTER), stearic (STEAR) or stearic interesterified (STEAR INTER). Plasma lipids, lipoprotein profile, arterial lesion area, macrophage infiltration, collagen content and inflammatory response modulation were determined.

Source: The Journal of Nutritional Biochemistry - March 4, 2016 Category: Biochemistry Authors: Milessa Silva Afonso, Maria Silvia Ferrari Lavrador, Marcia Kiyomi Koike, Dennys Esper Cintra, Fabiana Dias Ferreira, Valeria Sutti Nunes, Gabriela Castilho, Luiz Antonio Gioielli, Renata de Paula Assis Bombo, Sergio Catanozi, Elia Garcia Caldini, Nilsa R Source Type: research