Will intracytoplasmic morphologically selected sperm injection replace intracytoplasmic sperm injection in cases of severe oligo-astheno-teratozoospermia?: a prospective study

Objective: The aim of the study was to compare between intracytoplasmic morphologically selected sperm injection (IMSI) and conventional intracytoplasmic sperm injection (ICSI) as regards laboratory and clinical outcomes in couples with severe oligo-astheno-teratozoospermia (OAT). Design: This was a prospective, nonrandomized, controlled clinical trial. Setting: The study was conducted in the Agial ICSI/IVF Center. Materials and methods: A total of 1729 couples with severe OAT were enrolled: 1356 couples were submitted to routine ICSI (group I) and 373 couples were submitted to IMSI (group II) after they had been counselled about the possible role of the IMSI technique in increasing pregnancy rates. For IMSI, spermatozoa were selected at 6600× magnification using an inverted microscope. For conventional ICSI, spermatozoa were selected at 400× magnification. Main outcome measures: Laboratory (fertilization rate, embryo quality, number of embryos transferred) and clinical outcomes (clinical pregnancy rate) were compared between the two groups. Both groups were comparable regarding the number of mature (MII) oocytes collected (P=0.36) and the total number of embryos transferred (P=0.202). No statistically significant difference was observed between the two groups regarding rates of fertilization (P=0.946), with a mean±SD of 63.47±25.15% in group I and 64.69±22.66% in group II. However, a statistically significant difference (P
Source: Journal of Evidence-Based Women’s Health Journal Society - Category: OBGYN Tags: Original articles Source Type: research