Lead enhances fluoride influence on apoptotic processes in the HepG2 liver cell line

We examined hepatocytes from the liver cell line HepG2, incubated for 48 h with NaF, PbAc, and their mixture (NaF + PbAc), and used for measuring apoptosis, index of proliferation, and vitality of cells. Incubation of the hepatocytes with NaF or PbAc increased apoptosis, more when fluoride and Pb were used simultaneously. Vitality of the cells depended on the compound used and its concentration. Proliferation slightly increased and then decreased in a high fluoride environment; it decreased significantly after addition of Pb in a dose-dependent manner. When used together, fluoride inhibited the decreasing effect of Pb on cell proliferation.

Source: Toxicology and Industrial Health - March 3, 2016 Category: Toxicology Authors: Gutowska, I., Baranowska-Bosiacka, I., Siwiec, E., Szczuko, M., Kolasa, A., Kondarewicz, A., Rybicka, M., Dunaj-Stanczyk, M., Wiernicki, I., Chlubek, D., Stachowska, E. Tags: Articles Source Type: research