Treatment of Chronic Bone Infection

The treatment of chronic osteomyelitis depends on the obstinate persistence of the offending micro-organism(s) and often results in long-term patient disability causing remarkable costs to the health care system. Difficulties of treating chronic osteomyelitis derive from biofilm-forming pathogens that resist the host immunologic defense and antimicrobial substances, and the need to treat osseous defects that result from the disease itself and eventual previous interventions. Established surgical techniques require multiple costly operations with extended periods of disablement and impairment of the patients, sometimes making the therapy worse than the disease.

Source: Operative Techniques in Orthopaedics - January 26, 2016 Category: Orthopaedics Authors: Heinz Winkler, Peter Haiden Source Type: research