E2F1 transcription factor and its impact on growth factor and cytokine signaling

E2F transcription factor family members play critical roles in cell cycle regulation and apoptosis. The landmark paper published in 1986 showed that transcriptional induction of adenoviral E2 gene required a cellular protein in addition to adenoviral E1A [1]. Following this original paper, subsequent studies identified that cellular protein as so-called E2 factor (E2F) protein [2,3]. In 1991, a product of adenovirus E1A gene was shown to interact with retinoblastoma-related protein Rb [4], following this, in 1992, it was shown that Rb also binds to members of E2F transcription factor family [5].
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Survey Source Type: research