Na/K-ATPase signaling regulates collagen synthesis through microRNA-29b-3p in cardiac fibroblasts

In conclusion, these data are the first to indicate that signaling through Na/K-ATPase regulates miRNAs and specifically, miR-29b-3p expression both in vivo and in vitro. Additionally, these data indicate that miR-29b-3p expression plays an important role in the formation of cardiac fibrosis in CKD.

Source: Physiological Genomics - March 1, 2016 Category: Genetics & Stem Cells Authors: Drummond, C. A., Hill, M. C., Shi, H., Fan, X., Xie, J. X., Haller, S. T., Kennedy, D. J., Liu, J., Garrett, M. R., Xie, Z., Cooper, C. J., Shapiro, J. I., Tian, J. Tags: Regulation of Gene Expression Source Type: research