A Rare Cause of Lower Extremity Ulcers: Prolidase Deficiency

This study describes 4 patients with recurrent leg ulcerations and abnormal facies who were first clinically suspected of prolidase deficiency and then biochemically confirmed. Two siblings and 2 other patients were admitted to our clinic at different times, and they had some common features such as chronic leg and foot ulcers recalcitrant to treatment, consanguineous parents, facial dysmorphism, mental retardation, and widespread telangiectasias. Physical examination and detection of low prolidase level in blood finally led us to the diagnose of ulcers secondary to prolidase deficiency. Prolidase deficiency is a rare genodermatosis and must be considered in the differential diagnosis of recurrent leg and foot ulcers that develop at an early age.

Source: The International Journal of Lower Extremity Wounds - March 1, 2016 Category: Surgery Authors: Adısen, E., Erduran, F. B., Ezgü, F. S., Kasapkara, C. S., Besio, R., Forlino, A., Gürer, M. A. Tags: Case Reports Source Type: research