Preleukemic phase of chronic myelogenous leukemia: morphologic and immunohistochemical characterization of 7 cases

Patients with chronic myelogenous leukemia (CML) present typically with an elevated white blood cell count (WBC) and cytogenetic or molecular genetic evidence of t(9;22)/BCR-ABL1 fusion gene. Rarely, CML patients may present with a normal or mildly elevated WBC and are asymptomatic, and we describe 7 patients in this study. The WBC in these patients ranged from 3.6 to 14.3 K/mm3 with 50% to 73% granulocytes and 0% blasts. In all patients, t(9;22)(q34;q11.2) was detected by conventional cytogenetics, and BCR-ABL1 fusion was shown, supporting the diagnosis of preleukemic CML (pre-CML).

http://www.annalspathology.com/article/S1092-9134(15)30069-1/abstract?rss=yes

Source: Annals of Diagnostic Pathology - February 5, 2016 Category: Pathology Authors: Le Le Aye, Sanam Loghavi, Ken H. Young, Imran Siddiqi, C. Cameron Yin, Mark J. Routbort, Mei Liang, Keith Eilerman, L. Jeffrey Medeiros, Russell K. Brynes, Carlos Bueso-Ramos Source Type: research