Effect of Shen-yuan on haemodynamic and anti-inflammatory factors in a porcine model of acute myocardial infarction

This study aimed to investigate whether the cardioprotective effects from Shen-yuan are due to regulation of haemodynamics and inflammation in a porcine model of acute MI. Myocardial infarction was induced by left anterior descending coronary artery ligation. Low, moderate, and high doses of Shen-yuan treatment were started 1 week before MI and continued for 2 weeks after MI. Whole blood viscosity at 15 s–1 and platelet aggregation rate were significantly increased in the MI group, but were markedly attenuated by high doses of Shen-yuan. A moderate dose of Shen-yuan also restored decreased values of the peak rise of left ventricular pressure and left ventricular mean pressure after MI. Expression of the T regulatory cell marker forkhead box P3 (Foxp3)+ at 14 days post-MI was lower than that in the sham-operated group. Foxp3 was significantly up-regulated in the infarcted and non-infarcted zones of the left ventricle in the Shen-yuan treatment groups. Plasma interleukin-10 and transforming growth factor-β levels were elevated by Shen-yuan treatment in a dose-dependent manner. Shen-yuan elicits cardiovascular protection by its haemodynamic stabilization and anti-inflammatory effects after onset of MI in a porcine model.

Source: European Journal of Heart Failure Supplements - February 29, 2016 Category: Cardiology Authors: Liang, W.-Y., Liu, M.-L., Feng, X.-R., Zhang, Z.-L., Zhu, X.-Y., Li, Y.-J., Liu, A., Yin, H.-J. Tags: Articles Source Type: research