Decreased beige adipocyte number and mitochondrial respiration coincide with increased histone methyl transferase (9Ga) and reduced FGF21 gene expression in Sprague Dawley rats fed prenatal low protein and postnatal high fat diets

We have shown that prenatal low protein (LP) followed by postnatal high-fat (HF) diets results in a rapid increase in subcutaneous adipose tissue (subc-AT) mass in the offspring contributing to development of obesity and insulin resistance. Studies have shown that a key transcription factor PR domain containing 16 (PRDM16) and fibroblast growth factor 21 (FGF21) are involved in conversion of precursor cells into mitochondria (mt) enriched beige adipocytes (BA). Our hypothesis is that a maternal LP and postnatal HF diets increase the risk of obesity and insulin resistance in offspring, in part, by reducing the conversion of precursor cell into BA in the subc-AT of offspring.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research