Pomegranate extract and exercise provide additive benefits on improvement of immune function by inhibiting inflammation and oxidative stress in high-fat diet-induced obesity rats

Obesity is reported to be associated with immune dysfunction and a state of low-grade, chronic inflammation. Either pomegranate extract (PomE) or exercise (Ex) has been shown to have anti-obesity, anti-inflammatory and anti-oxidant effects. Nevertheless, no study has addressed the additive benefits of PomE and Ex on the restoration of obesity-induced immune defects. The present work aims to study the effect of PomE and Ex as a combined intervention on immune function and the underlying mechanism involved in inflammation and oxidative stress in rats with high fat diet (HFD)-induced obesity.

Source: The Journal of Nutritional Biochemistry - February 27, 2016 Category: Biochemistry Authors: Fei Zhao, Wentao Pang, Ziyi Zhang, Jialong Zhao, Xin Wang, Ye Liu, Xun Wang, Zhihui Feng, Yong Zhang, Wenyan Sun, Jiankang Liu Source Type: research