Clinical effects and pharmacokinetic variables of romifidine and the peripheral α2‐adrenoceptor antagonist MK‐467 in horses

ConclusionsCombined romifidine and MK‐467 prevented the cardiovascular changes commonly seen with romifidine but did not affect sedation quality.
Clinical relevanceCombined IV romifidine and MK‐467 can be used to attenuate the cardiovascular effects of romifidine, such as in horses with colic or undergoing general anaesthesia.

Source: Veterinary Anaesthesia and Analgesia - February 26, 2016 Category: Veterinary Research Authors: Annemarie Vries, Soile AE Pakkanen, Marja R Raekallio, Abel Ekiri, Mika Scheinin, Polly M Taylor, Outi M Vainio Tags: Research Paper Source Type: research