TANK-binding kinase 1-dependent or -independent signaling elicits the cell-type-specific innate immune responses induced by the adenovirus vector

In this study, to determine the impacts of viral nucleic acids on innate immune responses in vivo, we administered transgene-expressing Adv to Tbk1-deficient mice. The systemic Adv administration failed to induce type I interferons (type I IFNs) in the spleen, but not the liver, of Tbk1-deficient mice, resulting in the increase of transgene-expressing cells in the spleen, but not the liver. Moreover, Adv failed to induce type I IFNs in the bone-marrow-derived dendritic cells, but not the mouse embryonic fibroblasts, from Tbk1-deficient mice in vitro. These results support the idea that Adv elicit innate immunity in immune cells and non-immune cells in a TBK1-dependent and TBK1-independent manner, respectively.

Source: International Immunology - February 23, 2016 Category: Allergy & Immunology Authors: Tsuzuki, S., Tachibana, M., Hemmi, M., Yamaguchi, T., Shoji, M., Sakurai, F., Kobiyama, K., Kawabata, K., Ishii, K. J., Akira, S., Mizuguchi, H. Tags: Original Research Source Type: research