Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis

Conclusions and clinical relevanceMeloxicam OTMS had similar effects on peak vertical force, motor activity and pain sensitization as previously reported for oral meloxicam in OA cats. The tramadol–meloxicam combination provided no evident benefit over meloxicam alone, except for central hypersensitivity (assessed with RMTS). Further assessment of the potential toxicity of the combination is required prior to clinical use. Gingival administration was well accepted overall.

Source: Veterinary Anaesthesia and Analgesia - February 24, 2016 Category: Veterinary Research Authors: Beatriz P Monteiro, Mary P Klinck, Maxim Moreau, Martin Guillot, Paulo VM Steagall, Daniel K Edge, Jean‐Pierre Pelletier, Johanne Martel‐Pelletier, Dominique Gauvin, Jérôme RE Castillo, Eric Troncy Tags: Research Paper Source Type: research