Expression profile of Rab5, Rab7, tryptophan aspartate-containing coat protein, leprae lipoarabinomannan, and phenolic glycolipid-1 on the failure of the phagolysosome process in macrophages of leprosy patients as a viability marker of Mycobacterium leprae

Conclusion In M. leprae infection, Rab5, Rab7, and Lep-LAM play important roles in the failure of the phagolysosome process via a membrane trafficking pathway, while PGL-1 plays a role via blocking lysosomal activities. These inventions might be used for the development of an early diagnostic device in the future.
Source: International Journal of Mycobacteriology - Category: Infectious Diseases Source Type: research