Valproate, risperidone, and antibiotic levels

The antiepileptic drug valproate is frequently used in the treatment of manic episodes, either as monotherapy or combined with lithium, carbamazepine, or antipsychotics. Drug interaction with valproate secondary to its ability to inhibit drug elimination, as well as induction of its metabolism by concurrently administered drugs, is commonly reported. In particular, the carbapenem antibiotics have been reported to interact with valproate, resulting in lower valproic acid concentrations and loss of seizure control.1

Source: The Brown University Psychopharmacology Update - February 23, 2016 Category: Psychiatry Authors: Y. W. Francis Lam Tags: Drug ‐Drug Interactions Source Type: research