Airway tissue engineering for congenital laryngotracheal disease

Regenerative medicine offers hope of a sustainable solution for severe airway disease by the creation of functional, immunocompatible organ replacements. When considering fetuses and newborns, there is a specific spectrum of airway pathologies that could benefit from cell therapy and tissue engineering applications. While hypoplastic lungs associated with congenital diaphragmatic hernia (CDH) could benefit from cellular based treatments aimed at ameliorating lung function, patients with upper airway obstruction could take advantage from a de novo tissue engineering approach.

Source: Seminars in Pediatric Surgery - February 21, 2016 Category: Pediatrics Authors: Elizabeth Maughan, Flore Lesage, Colin R. Butler, Robert E. Hynds, Richard Hewitt, Sam M. Janes, Jan A. Deprest, Paolo De Coppi Source Type: research