Pre-clinical evaluation of eight DOTA coupled gastrin-releasing peptide receptor (GRP-R) ligands for in vivo targeting of receptor-expressing tumors
Conclusions:
Our results indicate that the NMeGly for Gly substitution and the Sta-Leu substitution at the C-terminus confer high serum stability while maintaining high receptor affinity, resulting in biodistribution properties that outperform those of the other peptides.
Source: Epidemiologic Perspectives and Innovations - Category: Epidemiology Authors: Antonella AccardoFilippo GalliRosalba MansiLuigi Del PozzoMichela AurilioAnna MoriscoPaola RinghieriAlberto SignoreGiancarlo MorelliLuigi Aloj Source Type: research
More News: Cancer | Cancer & Oncology | Epidemiology | Gastroenterology | Nanotechnology | Ovarian Cancer | Ovaries | Pancreas | Pancreatic Cancer | Prostate Cancer | Study