The ACTN3 R577X polymorphism affects the lipid profile and the prognosis of nutritional intervention in HIV positive patients

The hypothesis of the present study is that the polymorphisms in the APOC3, CEPT, ACE and ACTN3 genes can affect the outcome of nutritional intervention and the plasma lipid profile of HIV+ patients. To test the hypothesis, genetic material was collected from buccal cells, and serum was collected for biochemical analysis. Sixty-five patients were analyzed. The incorporation of protease inhibitor (PI) was more frequent in women (77% vs. 33% in men). Nutritional intervention improved anthropometric parameters independent of the genotype.

Source: Nutrition Research - February 17, 2016 Category: Nutrition Authors: Laura C.R. Aranalde, Bruna S. Pederzoli, Thais Marten, Flavio C. Barros, Rossana P. Basso, Jussara M. Silveira, Sandra C. Valle, Simone Pieniz, Ronaldo C. Araujo, Edgar J. Paredes-Gamero, Ines Schadock, Augusto Schneider, Carlos C. Barros Source Type: research