Oat β-glucan depresses SGLT1 and GLUT2 mediated glucose transport in intestinal epithelial cells (IEC-6)

Oat β-glucan consumption is linked to reduced risk factors associated with diabetes and obesity by lowering glycemic response and serum level of low-density lipoproteins. The purpose of this study was to identify the mechanism of action of oat β-glucan at the interface between the gut wall and the lumen responsible for attenuating glucose levels. We proposed that viscous oat β-glucan acts as a physical barrier to glucose uptake in normally absorptive gut epithelial cells IEC-6 by affecting the expression of intestinal glucose transporters.
Source: Nutrition Research - Category: Nutrition Authors: Source Type: research