“New Horizons for sedation: The ultrashort acting benzodiazepine Remimazolam”

Procedural sedation is used in 98% of endoscopies performed in the US. The predominant agents used are benzodiazepines, opioids and propofol. The optimal sedation depends on the procedure being performed and its duration. An ideal sedative would allow for flexible, rapid onset and offset of sedation with predictable short duration of action with minimal cardiopulmonary risk factors. Remimazolam is a novel “soft drug” with the characteristics of a benzodiazepine and organ-independent metabolism.Remimazolam binds selectively and with high affinity to the GABAA receptor, with no off-target activities.

Source: Techniques in Gastrointestinal Endoscopy - February 17, 2016 Category: Gastroenterology Authors: D.J. Pambianco, B.D. Cash Source Type: research