Expression of nerve growth factor and its receptors in the uterus of rabbits: functional involvement in prostaglandin synthesis

The aim of the present study was to evaluate: 1) the presence of nerve growth factor (NGF) and the neurotrophic tyrosine kinase receptor 1 (NTRK1) and nerve growth factor receptor (NGFR) in the rabbit uterus; and 2) the in vitro effects of NGF on PGF2α and PGE2 synthesis and on the PGE2-9-ketoreductase (PGE2-9-K) activity by the rabbit uterus. NGF, NTRK1, and NGFR were immunolocalized in the luminal and glandular epithelium and stroma cells of the endometrium. RT-PCR indicated the presence of mRNA for NGF, NTRK1, and NGFR in the uterus.

Source: Domestic Animal Endocrinology - February 18, 2016 Category: Endocrinology Authors: M. Maranesi, F. Parillo, L. Leonardi, P.G. Rebollar, B. Alonso, L. Petrucci, A. Gobbetti, C. Boiti, J. Arruda-Alencar, A. Moura, M. Zerani Source Type: research