Large-scale evaluation of in prostate cancer reveals diagnostic and prognostic biomarker potential at three molecular levels

Limitations of current diagnostic and prognostic tools for prostate cancer (PC) have led to over-diagnosis and over-treatment. Here, we investigate the biomarker potential of the SLC18A2 (VMAT2) gene for PC at three molecular levels. Thus, SLC18A2 promoter methylation was analyzed in 767 malignant and 78 benign radical prostatectomy (RP) samples using methylation-specific qPCR and Illumina 450K methylation microarray data. SLC18A2 transcript levels were assessed in 412 malignant and 45 benign RP samples using RNAseq data.

Source: Molecular Oncology - February 12, 2016 Category: Cancer & Oncology Authors: Christa Haldrup, Anne-Sofie Lynnerup, Tine Maj Storebjerg, Søren Vang, Peter Wild, Tapio Visakorpi, Christian Arsov, Wolfgang A. Schulz, Johan Lindberg, Henrik Grönberg, Lars Egevad, Michael Borre, Torben Falck Ørntoft, Søren Høyer, Karina Dalsgaard Source Type: research