Y-90 Radiomicrosphere Therapy for Colorectal Cancer Liver Metastases

At present, the systemic treatment of unresectable colorectal cancer liver metastases involves oxaliplatin and irinotecan–based chemotherapy regimens combined with targeted therapies such as bevacizumab (Avastin) and cetuximab (Erbitux). Radiation therapy, traditionally, is not considered a viable treatment modality owing to its unacceptably high hepatic toxicity, and still steering traditional wisdom or dogma that chemoradiation cannot be an oncological strategy for a stage IV disease. Selective internal radiation treatment with yttrium-90 (Y-90) radiomicrospheres has emerged as an effective liver-directed therapy with a favorable therapeutic ratio.

Source: Seminars in Nuclear Medicine - February 19, 2016 Category: Nuclear Medicine Authors: Seza A. Gulec Source Type: research