Plasma vitamins and essential trace elements in multi-drug resistant tuberculosis patients before and during chemotherapy

This study determined the plasma level of micronutrients (Fe, Zn, Cu, vitamins A, C, D and E) in MDR-TB patients before and throughout anti-TB chemotherapy. Plasma iron, zinc, copper, vitamins A, C, D and E were determined in twenty-four (24) MDR-TB patients before the commencement of anti-TB chemotherapy, 2months, 4months and 6months post-commencement of anti-TB chemotherapy, as well as in twenty (20) healthy controls. Plasma vitamin A level was significantly decreased before chemotherapy compared with controls. At 2months of anti-TB treatment there were significant decreases in plasma levels of iron, vitamins A, C and E compared to controls whereas plasma zinc level was significantly increased compared with levels before treatment. At 4months of treatment, plasma levels of copper and vitamin D were significantly increased while plasma vitamin E level was reduced significantly compared with controls. There were significant increases in iron, zinc, copper, vitamin A and vitamin D levels with decreased plasma levels of vitamins C and E at 4months of treatment compared with their levels before chemotherapy. At 6months of treatment, plasma levels of iron, zinc, copper and vitamin D were significantly increased while vitamin E was significantly decreased compared with controls. Plasma levels of iron, zinc, copper, vitamins A and D were significantly increased whereas the levels of vitamins C and E were significantly reduced at 6months of treatment compared with levels before chem...
Source: Egyptian Journal of Chest Diseases and Tuberculosis - Category: Respiratory Medicine Source Type: research